222 mg vs 444 mg
Compare the two amounts most often mentioned in community fenbendazole protocols and see how each fits into a weekly schedule.
Read the 222 mg vs 444 mg guideEducational tool
Fenbendazole Dosage Calculator & Protocols
Explore fenbendazole 222 mg and 444 mg schedules, the Joe Tippens protocol, the Makis combination protocol, and standalone research calculators for fenbendazole, ivermectin and BPC-157.
Important: This calculator is for educational and research purposes only. It is not medical advice and does not diagnose, treat, cure or prevent any disease. Always consult a licensed healthcare professional before starting any protocol.
Quick answers
Fenbendazole dosage and protocol facts
Short answer: there is no FDA-approved fenbendazole dosage for humans. The figures below describe publicly discussed community schedules, not a medical recommendation.
- Joe Tippens protocol
- Commonly described as 222 mg on three consecutive days followed by four rest days. It is anecdotal and not an approved cancer treatment.
- 222 mg vs 444 mg
- 444 mg is twice the 222 mg amount. Neither amount is an approved human dose, and a larger amount does not establish greater effectiveness.
- Makis protocol
- A community-described fenbendazole and ivermectin combination with protocol tiers and rest days. It is not a clinically established standard of care.
- What this calculator does
- It converts selected educational inputs into a transparent weekly schedule and dated calendar; it does not assess suitability, interactions, safety or treatment outcomes.
Guided protocols — full recipe
Single compound
Guided protocol
Dr. Makis Protocol
A combination oncology protocol that pairs ivermectin with a benzimidazole (fenbendazole) plus metabolic support. Choose a severity tier — both doses are set automatically, and you can fine-tune each with its own slider.
Most common solid tumors — breast, lung, colon, prostate, renal. Dosed 6 days on, 1 day off.
💊 Step 1 · Ivermectin
Anti-parasitic repurposed for oncology. Dose per kg of body weight, 6 days on / 1 day off, taken with a fatty meal (boosts absorption ~2.5×).
Dose per kg1.00 mg/kg
70 mg / day
Ivermectin ≈ 5.8 × 12 mg tablets
Ivermectin safety zone
01.02.02.5
✅ Prevention–standard range (≤ 1.0 mg/kg per Makis tiers).
Green · standard≤ 1.0 mg/kg — prevention to standard tiers
Yellow · supervised1.0–2.0 mg/kg — aggressive tier, medical supervision
Red · critical only> 2.0 mg/kg — late-stage / strict monitoring only
🧬 Step 2 · Fenbendazole
Benzimidazole anti-parasitic paired with ivermectin in the Makis combination. Per-dose amount, 6 days on / 1 day off (or mebendazole 200–1500 mg).
Daily dose444 mg
444 mg / day
Fenbendazole (or mebendazole 200–1500 mg)
Fenbendazole safety zone
22244410001332
✅ Fenbendazole within the standard Makis range (222–444 mg).
Green · standard222–444 mg/day — standard Makis range
Yellow · high-grade444–1000 mg/day — high-grade cancers, supervised
Red · specific cases> 1000 mg/day — above typical ceiling, strict monitoring
🧾 The Makis combination stack
✓
Ivermectin — 70 mg per dose
Human pharmaceutical 12 mg tablets, 6 days on / 1 day off, taken with a high-fat meal to boost absorption ~2.5×.
✓
Fenbendazole — 444 mg per dose
Or mebendazole 200–1500 mg. Benzimidazole partner for synergy, 6 days on / 1 day off.
✓
Vitamin D3 — 5,000–10,000 IU / day
The same D3 softgels sold in any pharmacy — just a high daily dose (most shelf bottles are 1,000–2,000 IU). The goal is a strong blood level (a “25-OH vitamin D” lab test around 70–90 ng/mL); ask your doctor to check it every few months and adjust.
✓
Berberine — 500 mg
Daily. Metabolic support (glucose/glutamine restriction rationale).
+
Optional — Methylene blue
Reserved for aggressive cases, physician-directed only.
Protocol also emphasizes a ketogenic diet or intermittent fasting. Monitor liver (ALT/AST) & kidney function every 2–6 weeks.
Weekly dosing schedule
Standard tier runs 6 days on, 1 day off. Green = dose day. Prevention tier often runs ~3 days/week.
Sun
DOSE
Mon
DOSE
Tue
DOSE
Wed
DOSE
Thu
DOSE
Fri
DOSE
Sat
REST
6 dosing days per week · ivermectin 70 mg + fenbendazole 444 mg
📅 Day-by-day protocol calendar
Loading your personalized calendar…
Possible side effects
- Ivermectin — neurotoxicity at high doses: dizziness, blurred vision, confusion, loss of balance; severe cases seizures/coma. Accumulates with daily dosing (half-life ~18 h).
- Combined liver strain — ivermectin + benzimidazole together stress the liver; LFT monitoring every 2–4 weeks is standard.
- Drug interactions — ivermectin is a CYP3A4 / P-glycoprotein substrate; interacts with blood thinners and some chemo agents.
- Never use veterinary-grade products — use human pharmaceutical-grade with a Certificate of Analysis.
Disclaimer. These medications are not FDA-approved for cancer. The protocol relies on preclinical data and observational cohorts (e.g. Hulscher et al. 2026, no control group), not Phase 3 trials. Even Dr. Paul Marik has cautioned against high-dose regimens. Use only under qualified medical supervision.
Branded 2TheLife summary with the full combination, schedule & safety notes.
🛒 Get the products for this protocol
Educational reference
Fenbendazole dosage calculator and protocol guide
There is no FDA-approved fenbendazole dosage for humans. This tool does not prescribe a dose. It organizes commonly searched, publicly discussed schedules so you can compare amounts, dosing days, rest days and safety considerations before speaking with a licensed clinician.
Weekly protocol calendar
Visualize dosing and rest days, set a start date, and download the same day-by-day educational schedule shown on the page.
Open the fenbendazole calculatorSafety and evidence limits
Review the lack of an approved human dose, limited clinical evidence, liver-injury reports and the need to discuss interactions with a clinician.
Read the fenbendazole dosage guideFenbendazole protocols included
Joe Tippens protocol calculator
Explore the widely discussed 222 mg, 3-days-on / 4-days-off schedule alongside the protocol's commonly cited adjuncts.
Makis protocol calculator
Review a community-described fenbendazole and ivermectin combination schedule with adjustable weight and protocol tiers.
Standalone fenbendazole protocol
Compare flat-dose research schedules, 222 mg and 444 mg amounts, safety zones, weekly dosing patterns and a dated calendar.
Fenbendazole research and protocol guides
Use these evidence-focused guides to understand what the protocols claim, what is actually known, and where the evidence remains limited.
Questions